Reduced Expression Of Myc Increases Longevity And Enhances Healthspan Pdf

File Name: reduced expression of myc increases longevity and enhances healthspan .zip
Size: 1581Kb
Published: 01.06.2021

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease.

Address correspondence to Haim Y. E-mail: Haim. Cohen biu. The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases.

Reducing Myc gene increases lifespan of mice by 15% on average

A team of scientists based at Brown University has found that reducing expression of a fundamentally important gene called Myc significantly increased the healthy lifespan of laboratory mice, the first such finding regarding this gene in a mammalian species. Myc is found in the genomes of all animals, ranging from ancestral single-celled organisms to humans. It is a major topic of biomedical research and has been shown to be a central regulator of cell proliferation, growth, and death. It is of such widespread and fundamental importance that animals cannot live without it. But in humans and mice, too much expression of the protein that Myc encodes has been closely linked to cancer, making it a well-known but elusive target of drug developers.

Centenarians

Citazioni per anno. Citazioni duplicate. I seguenti articoli sono uniti in Scholar. Le loro citazioni combinate sono conteggiate solo per il primo articolo. Citazioni unite. Questo conteggio "Citato da" include citazioni ai seguenti articoli in Scholar. Aggiungi coautori Coautori.


Reduced Expression of MYC Increases Longevity and Enhances Healthspan (alpost103.org). Myc+/– Mice Show Evidence of Improved Healthspan in Multiple Tissues.


Reducing Myc gene increases lifespan of mice by 15% on average

This state-of-the-art review on longevity focuses on centenarians, studied as a model of positive biology. The extraordinary rise in the elderly population in developed countries underscores the importance of studies on ageing and longevity in order to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies. Centenarians have reached the extreme limits of human life span. Those in relatively good health, who are able to perform their routine daily tasks, are the best examples of extreme longevity, representing selected individuals in which the appearance of major age-related diseases — including cancer and cardiovascular diseases — has been consistently delayed or avoided.

Oncotarget a primarily oncology-focused, peer-reviewed, open access, biweekly journal aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Its scope is unique. The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. The term was introduced in the inaugural Editorial , Introducing OncoTarget.

So far, several longevity mouse models have been developed containing mutations related to growth signaling deficiency by targeting growth hormone GH , IGF1, IGF1 receptor, insulin receptor, and insulin receptor substrate. In addition, p70 ribosomal protein S6 kinase 1 S6K1 knockout leads to lifespan extension. S6K1 encodes an important kinase in the regulation of cell growth. S6K1 is regulated by mechanistic target of rapamycin mTOR complex 1.

Address correspondence to Haim Y.

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.

Мы столкнулись с врагами, которые, как мне казалось, никогда не посмеют бросить нам вызов. Я говорю о наших собственных гражданах. О юристах, фанатичных борцах за гражданские права, о Фонде электронных границ - они все приняли в этом участие, но дело в другом. Дело в людях. Они потеряли веру.

3 Response
  1. Ben C.

    Article. Reduced Expression of MYC Increases Longevity and Enhances Healthspan. Jeffrey W. Hofmann,1,7 Xiaoai Zhao,1,7 Marco De Cecco.

  2. Fabiano A.

    Request PDF | Reduced Expression of MYC Increases Longevity and Enhances Healthspan | MYC is a highly pleiotropic transcription factor.

Leave a Reply